{"id":76,"date":"2021-09-28T08:08:03","date_gmt":"2021-09-28T08:08:03","guid":{"rendered":"https:\/\/www.mediterranea-theranostic.com\/?page_id=76"},"modified":"2022-01-20T10:52:17","modified_gmt":"2022-01-20T10:52:17","slug":"progetti","status":"publish","type":"page","link":"https:\/\/www.mediterranea-theranostic.com\/it\/progetti\/","title":{"rendered":"Progetto"},"content":{"rendered":"\t\t
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PRODOTTI<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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MERCATO<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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COMPETITORS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"pexels-chokniti-khongchum-2280547\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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RISORSE CHIAVE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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PRODOTTI<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Trop-2 \u00e8 espresso da circa i due terzi dei cancri nell’ uomo. L\u2019anticorpo Hu-2G10 \u00e8 stato disegnato per riconoscere solo la forma cancro-specifica di Trop-2. Quindi si presenta come farmaco con specificit\u00e0 essenzialmente assoluta anti-cancro. MT ha stretto accordi di R&D con partners europei, statunitensi e asiatici per lo sviluppo di ADC basati su Hu2G10 di potenza massima e con ridotta tossicit\u00e0. Questi ADC hanno dimostrato notevole efficacia in test pilota in modelli preclinici.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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MERCATO<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Previsioni di riferimento indicano per gli anticorpi anti-Trop-2 uno dei pi\u00f9 grandi mercati esistenti per un farmaco anticancro. In Europa e Stati Uniti i tumori pi\u00f9 frequenti sono i tumori al polmone, seno, colon, ovaio, con 1.000.000 nuovi casi\/anno; di questi almeno i due terzi esprimono Trop-2. I tumori candidati a terapia con anticorpi anti-Trop-2 sono 650.000 nuovi casi\/anno, il costo medio annuo per paziente \u00e8 di 30.000 \u20ac\/anno per una dimensione di mercato di 10 miliardi \u20ac\/anno. Farmaco di riferimento \u00e8 l\u2019anticorpo anticancro Herceptin per il tumore al seno, con vendite annue che ammontano a 7 miliardi \u20ac.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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COMPETITORS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Immunomedics ha generato l\u2019anticorpo RS7 umanizzato coniugato a SN38 (Sacituzumab Govitecan, IMMU-132). Questo ADC tuttavia \u00e8 basato su tecnologie sorpassate (riduzione dei ponti disolfuro). Tecnologie simili sono state recentemente implementate da Daiichi Sankyo con l\u2019 ADC anti-Trop-2 DS-1062, attualmente in sperimentazione sul cancro del polmone, ottenendo risultati corrispondenti. Tecnologie innovative di coniugazione e l\u2019utilizzo di tossine di potenza elevatissima possono permettere all\u2019ADC anti-Trop-2 Hu2G10 di diventare \u201cbest in class\u201d.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"pexels-chokniti-khongchum-2280547\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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RISORSE CHIAVE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Leadership internazionale nel campo della ricerca su Trop-2\u00a0<\/p>

Rete di collaboratori e partners esperti\u00a0<\/p>

Portfolio IP a livello globale, con brevetti chiave in corso di concessione o gi\u00e0 concessi (WO2016087651; WO2017084763).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

PRODOTTI MERCATO COMPETITORS RISORSE CHIAVE PRODOTTI Trop-2 \u00e8 espresso da circa i due terzi dei cancri nell’ uomo. L\u2019anticorpo Hu-2G10 \u00e8 stato disegnato per riconoscere solo la forma cancro-specifica di Trop-2. Quindi si presenta come farmaco con specificit\u00e0 essenzialmente assoluta anti-cancro. MT ha stretto accordi di R&D con partners europei, statunitensi e asiatici per lo […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_front_end_style_editor":"no","ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"on","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","footnotes":""},"class_list":["post-76","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nProgetto - mediterranea-theranostic<\/title>\n<meta name=\"description\" content=\"Trop-2 \u00e8 espresso da circa i due terzi dei cancri nell\u2019uomo. L\u2019anticorpo Hu-2G10 \u00e8 stato disegnato per riconoscere solo la forma cancro-specifica di Trop-2.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mediterranea-theranostic.com\/it\/progetti\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Progetto - mediterranea-theranostic\" \/>\n<meta property=\"og:description\" content=\"Trop-2 \u00e8 espresso da circa i due terzi dei cancri nell\u2019uomo. 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